49ers Schedule 2025 Season. The san francisco 49ers’ regular season began on september 9, 2024, and will end on january 5, 2025. Following their week 17 matchup versus the detroit lions, the san francisco 49ers will close out the year as the no.
San francisco 49ers 2025 schedule. But as the calendar flips to 2025, kyle shanahan’s team provided some reasons for future optimism on monday night.
